Titre : | Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans |
Titre traduit : | (Chez l'homme, la cocaïne active les plaquettes et augmente la formation de plaquettes contenant des micro-aggrégats.) |
Auteurs : | HEESCH C. M. ; C. R. WILHELM ; RISTICH J. ; J. ADNANE ; BONTEMPO F. A. ; W. R. WAGNER |
Type de document : | Périodique |
Année de publication : | 2000 |
Format : | 688-695 / graph. ; ill. ; tabl. |
Note générale : |
Heart, 2000, (83), 688-695 |
Langues: | Anglais |
Mots-clés : |
Thésaurus mots-clés COCAINE ; PATHOLOGIE ORGANIQUE ; APPAREIL CARDIOVASCULAIRE ; THROMBOSE ; INFARCTUS |
Résumé : |
FRANÇAIS : Les conclusions de cette étude confirment que la cocaïne même à faible dose et en usage occasionnel peut favoriser la thrombose et prédisposer des individus sains à des accidents ischémiques. ENGLISH : Objective: To determine whether there is evidence of platelet activation following in vivo cocaine administration in humans, as cocaine abuse is associated with myocardial infarction and stroke, and platelet activation leading to thrombosis is a possible mechanism. Setting: University hospital. Design and subjects: Following a randomised, double blind crossover design, 14 healthy volunteers were studied twice, receiving cocaine (2 mg/kg intranasally) once and placebo once. Flow cytometric analysis of P-selectin expression (an a granule membrane protein found on the surface of activated platelets), quantification of the platelet specific proteins platelet factor 4 and B thromboglobulin, and measurement of platelet containing microaggregate and platelet microparticle (fragment) formation were used to assess platelet activation. Circulating von Willebrand factor antigen (vWF) was measured to evaluate a possible role of endothelial stimulation concurrent with platelet activation. Results: There was an increase in both platelet factor 4 (mean (SD), 16 (7) to 39 (22) IU/ml, p=0.04) and B thromboglobulin (70 (20) to 98 (26) IU/ml, p |
Note de contenu : | graph. ; ill. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 42 |
Affiliation : |
Dprt of Medicine, Univ. Pittsburgh Medical Center, 328 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261 Etats-Unis. United States. |
Numéro Toxibase : | 206000 |
Centre Emetteur : | 02 Coordonnateur |
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