Titre : | Within- and between-subject variability in the reinforcing and subjective effects of nitrous oxide in healthy volunteers |
Titre traduit : | (Renforcement des effets subjectifs du protoxyde d'azote chez des volontaires sains : variabilité inter et intra individus) |
Auteurs : | D. J. WALKER ; J. P. ZACNY |
Type de document : | Rapport |
Année de publication : | 2001 |
Format : | 85-96 |
Note générale : |
Drug and Alcohol Dependence, 2001, 64, (1), 85-96
|
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés PROTOXYDE D'AZOTE ; INHALANTS ; CONDITIONNEMENT ; POTENTIEL ADDICTIF ; FACTEUR DE VULNERABILITE |
Résumé : | Within- and between-subject variability in the reinforcing and subjective effects of nitrous oxide (N2O) was studied across five sessions. Twelve volunteers with no history of drug dependence sampled 30% N2O and 100% oxygen for 10 min each, then chose nine times, once every 5 min, among N2O (e.g. "Agent A"), oxygen (e.g. "Agent B"), or "drug-free air." Choice varied across subjects but was stable within subjects. Quantitative differences in subjective effects occurred within and across subjects. Some subjective effects were correlated with choice and/or differed between subjects who were consistent choosers of N2O versus those who were not. However, drug liking and euphoria, two face-valid measures of abuse liability, were unrelated to choice. Thus, the present study found individual differences (i.e. between-subject variability) in subjective and reinforcing effects of N2O and, in terms of within-subject variability, suggested that subjective effects fluctuate across sessions to a relatively greater extent than do reinforcing effects. The varying degrees of correlation between N2O choice and its subjective effects emphasize the need for obtaining multiple measures when characterizing abuse liability of this drug. (Author's abstract.) |
Domaine : | Autres substances / Other substances |
Affiliation : |
Univ. Chicago, Dept. Anesthesia Critical Care 5841 S. Maryland Ave., MC 4028 Chicago, IL 60637 Etats-Unis. United States. |
Numéro Toxibase : | 803712 |
Centre Emetteur : | 08 CAS Strasbourg |
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