Titre : | GABAb receptor agonists for the treatment of drug addiction : a review of recent findings |
Titre traduit : | (Revue des résultats récents concernant les agonistes des récepteurs du GABAb utilisés dans le traitement des addictions) |
Auteurs : | M. S. COUSINS ; D. C. S. ROBERTS ; H. DE WIT |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 209-220 / graph. |
Note générale : |
Drug and Alcohol Dependence, 2002, 65, (3), 209-220 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés HEROINE ; COCAINE ; ALCOOL ; NICOTINE ; GABA ; DEPENDANCE ; AGONISTE ; AUTOADMINISTRATION ; RENFORCEMENT ; PHARMACOTHERAPIE |
Résumé : |
ENGLISH : A growing preclinical and clinical literature suggests that GABA B receptor agonists promote abstinence and reduce the use of cocaine, heroin, alcohol and nicotine. The purpose of this paper is to critically review these data. GABA B receptor agonists, such as baclofen, appear to reduce the reinforcing effects of abused drugs in animal models under multiple experimental procedures. This occurs at doses that have little effect on responding for other positive reinforcers such as food or water. We review evidence that these potential therapeutic effects may be mediated by modulation of mesolimbic dopamine neurons. This review also examines the preliminary clinical data from studies of the efficacy of baclofen for treatment of cocaine, alcohol, and nicotine dependence. We suggest that these preliminary data provide a rationale for conducting more systematic studies of the effects of GABA B receptor agonists as treatment for drug abuse. This line of research may also improve our understanding of the neurochemical mechanisms underlying the drug dependence process. (Author's abstract.) |
Note de contenu : | graph. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 81 |
Affiliation : |
Dept Psychiatr., Univ. Chicago, 5841 S. Maryland Ave., Chicago, IL 60637 Etats-Unis. United States. |
Numéro Toxibase : | 803756 |
Centre Emetteur : | 08 CAS Strasbourg |
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