Titre : | An exploratory study: the use of paroxetine for metamphetamine craving |
Titre traduit : | (Etude exploratoire : l'utilisation de paroxetine dans le traitement du manque de métamphétamines) |
Auteurs : | PIASECKI M. P. ; STEINAGEL G. M. ; THIENHAUS O. J. ; KOHLENBERG B. S. |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 301-304 / tabl. |
Note générale : |
Journal of Psychoactive Drugs, 2002, 34, (3), 301-304 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés METHAMPHETAMINE ; MANQUE ; TRAITEMENT ; ANTIDEPRESSEURS |
Résumé : |
ENGLISH : Methamphetamine abuse and dependence are growing problems nationally and worldwide. There are currently no effective pharmocologic treatments. Animal studies with SSRI's suggest that serotonergic modulation alters methamphetamine's behavioral effects. This exploratory study is a trial of the effects of the SSRI paroxetine versus placebo (in a double blind design) on craving and use in a population of methamphetamine users. Many subjects dropped out of the study, but those in active treatment who completed the eight week trial had a decrease in methamphetamine craving compared to the placebo treatment as measured by the OCDS modified for use in this population. Statistical analyses were not performed due to the low number of subjects. The preliminary data suggest that serotonergic agents may play a role in the effective treatment of methamphetamine abuse and dependence within the context of other effective behavioral interventions. (Author's abstract.) |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 22 |
Affiliation : |
Univ. Navada Sch. Med., Dept Psychiat. 354 Reno, NV 89557-0046 piaseckimed.unr.edu Etats-Unis. United States. |
Numéro Toxibase : | 102376 |
Centre Emetteur : | 01 Pey Berland |
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