Titre : | History and current status of opioid maintenance treatments: blending conference session |
Titre traduit : | (Historique et état actuel du traitement de maintenance des opiacés : unir les séances de l'Assemblée) |
Auteurs : | M. J. KREEK ; F. J. VOCCI |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 93-105 |
Note générale : |
Journal of Substance Abuse Treatment, 2002, 23, (2), 93-105 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés OPIACES ; TRAITEMENT DE MAINTENANCE ; BUPRENORPHINE ; METHADONE ; EFFICACITE ; REGLEMENTATIONThésaurus géographique ETATS-UNIS |
Résumé : |
ENGLISH : Opiate addiction is a chronic, relapsing disorder. Left untreated, high morbidity and mortality rates are seen. Pharmacotherapies for this disorder using mu opiate agonists (methadone and levomethadyl acetate) and partial agonists have been developed in the last 40 years. Agonist pharmacotherapy with oral methadone for the treatment of opiate dependence was developed in clinical pharmacology studies at Rockefeller University by Dole, Nyswander, and Kreek. Further studies by this laboratory and others established that moderate to high dose treatment with methadone (80-120 mg) reduced or eliminated opiate use in outpatient settings with consequent reductions in morbidity and up to 4-fold reductions in mortality. Levomethadyl acetate (LAAM), a congener of methadone, is biotransformed to active metabolites responsible for its longer duration of action. The Federal Regulations regarding the dispensation of methadone and LAAM have recently been revised to facilitate the treatment of patients under a "medical maintenance" model. Future regulatory reform will likely involve the establishment of rules for "office based opioid treatment." (Editor's abstract.) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 110 |
Affiliation : |
Laboratory Biology Addictive Diseases, Rockefeller Univ. Hosp, New York, NY 10021. E-mail : fv6k@nih.gov Etats-Unis. United States. |
Numéro Toxibase : | 403985 |
Centre Emetteur : | 04 CIRDD-51 |
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