Titre : | A randomized trial comparing levo-alpha acetylmethadol with methadone maintenance for patients in primary care settings in Australia |
Titre traduit : | (Un essai randomisé comparant la maintenance au levo-alpha acéthylméthadol -LAAM - et à la méthadone parmi des patients dans un centre de soins primaires en Australie.) |
Auteurs : | A. J. RITTER ; N. LINTZERIS ; N. CLARK ; KUTIN J. J. ; G. BAMMER ; PANJARI M. |
Type de document : | Périodique |
Année de publication : | 2003 |
Format : | 1605-1613 / fig. ; tabl. |
Note générale : |
Addictions, 2003, 98, (11), 1605-1613 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés LAAM ; METHADONE ; TRAITEMENT DE MAINTENANCE ; MEDECIN GENERALISTE ; EFFICACITE ; COMPARAISON ; EPIDEMIOLOGIE DESCRIPTIVEThésaurus géographique AUSTRALIE |
Résumé : |
FRANÇAIS : Les 93 participants de l'étude ont été recrutés auprès de 29 médecins généralistes et suivis à 3, 6 et 12 mois. La rétention en traitement, l'auto-évalution d'un usage d'héroïne et la survenue d'effets secondaires graves sont les trois mesures d'évaluation de l'efficacité des 2 produits de substitution. Aucune différence significative n'a été observée entre les 2 groupes concernant la rétention en traitement ou l'usage d'héroïne. Quatre effets secondaires graves ont été signalés dans le groupe en maintenance au LAAM. Cette étude démontre l'efficacité du LAAM dans le traitement de la dépendance à l'héroïne et la possibilité de sa dispensation en médecine générale. ENGLISH : Aims: The present study aimed to compare the efficacy of levo-alpha-acetyl-methadol (LAAM) and methadone, as measured by retention in treatment and heroin use, in a randomized trial conducted under naturalistic conditions. Setting: This study is the first randomized trial comparing LAAM with methadone in the primary care setting. Participants were recruited through 29 medical practitioners working in specialist and generalist settings in Australia. Participants: Existing methadone maintenance patients, aged 18 years and over and able to give informed consent, were randomized to receive either LAAM or methadone. A total of 93 patients participated. Intervention: After being trained in the use of LAAM, existing methadone prescribers were then able to determine an individually tailored treatment regimen for each patient. The trial was an open-label study. Methadone and LAAM dosing was supervised through local community pharmacies. Participation in ancillary services (e.g. counselling) was optional for all patients.The treatment period for the trial was 12 months. Measurements: Baseline. 3-, 6- and 12-month interviews were conducted. Outcome measures were retention in treatment, self reported heroin use and serious adverse events. Findings: There were no significant differences between LAAM and methadone on retention in treatment, nor heroin use. There was a trend for LAAM patients to have lower heroin use than methadone patients. Of the seven serious adverse events in the LAAM group, three were not drug-related. There were two dosing errors. Conclusions: This study demonstrates (a) the efficacy of LAAM as a treatment for heroin dependence, and (b) the capacity for LAAM to be effectively delivered in primary care settings by trained general practitioners and pharmacists. The next challenge is to resolve outstanding safety concerns with LAAM. (Author' s abstract) |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 23 |
Affiliation : |
Turning Point Alcohol and Drug Ctre, 54-62 Gertrude St., Fitzroy, VIC 3065. E-mail: alisonrturningpoint.org.au Australie. Australia. |
Numéro Toxibase : | 207210 |
Centre Emetteur : | 02 Coordonnateur |
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