Titre : | Clinical efficacy of buprenorphine: comparisons to methadone and placebo (2003) |
Titre traduit : | (Efficacité clinique de la buprénorphine : comparaison avec la méthadone et un placebo) |
Auteurs : | W. LING ; D. R. WESSON |
Type de document : | Article : Périodique |
Dans : | Drug and Alcohol Dependence (Vol.70, n°2 Suppl., May 2003) |
Article en page(s) : | S49-S57 |
Note générale : |
Drug and Alcohol Dependence, 2003, 70, (2, Suppl. 1), S49-S57 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; METHADONE ; PLACEBO ; TRAITEMENT DE MAINTENANCE ; EFFICACITE ; COMPARAISON |
Résumé : |
ENGLISH : The early clinical studies suggested that, in clinical settings, buprenorphine was a safe and efficacious opiate dependence pharmacotherapy. Formal approval for general clinical use, however, required that systematic data be gathered on buprenorphine's safety and efficacy in larger groups and a series of controlled clinical trials was designed to evaluate its utility from a medication development perspective. In general, these trials adhered to one of three basic protocol designs: comparison of buprenorphine to methadone; dose comparisons using dose response as an indicator of efficacy; and comparison of buprenorphine to placebo. Retention in treatment, reduction in illicit drug use and craving, and patient and staff ratings of improvements were the most frequently used outcome indicators in these trials. Additional data collected included optimum dosing and dosage schedules, adverse reactions and common side-effects, and other information intended to clarify buprenorphine's benefit-risk relationship and to help prepare guidelines for its safe marketing and utilization by physicians in general clinical practice. This paper presents a review of the buprenorphine/methadone comparison trials conducted in the United States and two such trials conducted in Europe. Also reviewed are three placebo-controlled trials and a buprenorphine/methadone detoxification study. Overall, this series of studies did firmly establish the efficacy of buprenorphine alone and in comparison to methadone. (Review's abstract.) |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 20 |
Affiliation : |
Integrated Substance Abuse Programme, Sch. Med., Univ. CA Los Angeles, 11075 Santa Monica blvd, Los Angeles, CA 90025 Etats-Unis. United States. |
Numéro Toxibase : | 804404 |
Centre Emetteur : | 08 CAS Strasbourg |
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