Titre : | Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal : a pharmacokinetic and pharmacodynamic analysis |
Titre traduit : | (Le LAAM : traitement alternatif pendant la maintenance à la méthadone chez des patients qui expérimentent régulièrement le sevrage. Une analyse pharmacocinétique et pharmacodynamique) |
Auteurs : | D. A. L. NEWCOMBE ; BOCHNER F. ; J. M. WHITE ; SOMOGYI A. A. |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 63-72 / graph. ; tabl. |
Note générale : |
Drug and Alcohol Dependence, 2004, 76, (1), 63-72 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés METHADONE ; LAAM ; RETENTION ; TRAITEMENT DE MAINTENANCE ; COMPARAISON ; EFFICACITE |
Résumé : |
ENGLISH : The aim of this study was to determine if substitution of daily methadone with second daily levo-alpha-acetylmethadol (LAAM) would convert non-holders on methadone into holders on LAAM, and to compare plasma concentrationtime profiles of (R)-methadone with LAAM and its two metabolites. Sixteen stable methadone maintenance treatment participants (non-holders, n=8) were randomly allocated to continue methadone for 3 months or switch to LAAM for 3 months, and then crossed over to the alternative drug for 3 months. At steady state, there were two testing sessions (24 h for methadone and 48 h for LAAM), during which opioid withdrawal severity, respiration rate and pupil diameter were measured 1011 times and venous blood was collected 1315 times. Ten age- and gender-matched controls underwent one 48-h test session. Areas under the withdrawal severity score versus time curve (AUC047 hours for LAAM and controls; AUC024 * 2 for methadone) were similar in holders on methadone and LAAM (P=0.62), but were greater in non-holders when they were taking methadone than LAAM (P |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 41 |
Affiliation : |
Dept. Clinic. Experim. Pharmacol., Univ. Adelaide, Adelaide 5005 ; jason.whiteadelaide.edu.au Australie. Australia. |
Numéro Toxibase : | 804707 |
Centre Emetteur : | 08 CAS Strasbourg |
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