Titre : | Incidence and risk factors for hepatitis C seroconversion in injecting drug users in Australia |
Titre traduit : | (Incidence et facteurs de risque d'une séroconversion au virus de l'hépatite C parmi des usagers de drogues par injection en Australie.) |
Auteurs : | L. MAHER ; B. JALALUDIN ; K. G. CHANT ; R. JAYASURIYA ; T. SLADDEN ; J. M. KALDOR ; P. L. SARGENT |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 1499-1308 / fig. ; tabl. |
Note générale : |
Addiction, 2006, 101, (10), 1499-1308
|
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés HEPATITE ; INJECTION ; INCIDENCE ; FACTEUR DE RISQUEThésaurus géographique AUSTRALIE |
Résumé : | Aims: To determine the incidence of hepatitis C virus (HCV) infection and identify risk factors for seroconversion. Design: Prospective cohort study. Participants were recruited through direct approaches, street-based outreach, methadone and sexual health clinics and needle and syringe programmes. Setting: Urban, regional and rural settings in New South Wales, Australia. Participants: Injecting drug users (IDUs) (n = 584) were screened and tested for exposure to HCV. Between 1999 and 2002 antibody HCV negative IDUs (n = 368) were enrolled and followed-up every 36 months until seroconversion or study completion. Measurements: Interviewer-administered baseline and follow-up questionnaires consisted of 131 items and included demographics, drug use and risk behaviour. Approximately 10 cc of whole blood was drawn at each visit. Specimens were stored at -70C and serology performed using one or two third-generation enzyme-linked immunosorbent assays and polymerase chain reaction testing. Findings: Sixty-eight seroconversions were observed and incidence was 30.8 per 100 person-years, with incidence in IDUs injecting |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 36 |
Affiliation : |
National Centre in HIV Epidemiology and Clinical Research, Level 2, St Vincent's Medical Centre, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. France. France. |
Numéro Toxibase : | 208882 |
Centre Emetteur : | 02 Coordonnateur |
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