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Auteur M. P. GARCIA-PORTILLA
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A 25-year follow-up of patients admitted to methadone treatment for the first time: Mortality and gender differences / L. JIMENEZ-TREVINO ; P. A. SAIZ ; M. P. GARCIA-PORTILLA ; E. M. DIAZ-MESA ; F. SANCHEZ-LASHERAS ; P. BURON ; M. J. CASARES ; P. MARINA ; E. GUTIERREZ ; J. BOBES in Addictive Behaviors, Vol.36, n°12 (December 2011)
in Addictive Behaviors > Vol.36, n°12 (December 2011) . - 1184-1190
Titre : A 25-year follow-up of patients admitted to methadone treatment for the first time: Mortality and gender differences Type de document : Périodique Auteurs : L. JIMENEZ-TREVINO ; P. A. SAIZ ; M. P. GARCIA-PORTILLA ; E. M. DIAZ-MESA ; F. SANCHEZ-LASHERAS ; P. BURON ; M. J. CASARES ; P. MARINA ; E. GUTIERREZ ; J. BOBES Année de publication : 2011 Article en page(s) : 1184-1190 Langues : Anglais Mots-clés : Thésaurus Géographique
METHADONE ; TRAITEMENT DE MAINTENANCE ; SUIVI DU PATIENT ; ETUDE PROSPECTIVE ; MORTALITE ; HEROINE ; DIFFERENCE DE GENRE ; RETENTION
Discipline : TRA Traitement et prise en charge / Treatment and care Domaine : Drogues illicites / Illicit drugs Résumé : Introduction: We conducted a follow-up study to evaluate the outcome of a heroin-dependent population 25 years after their first enrollment in methadone maintenance treatment (MMT). We assessed mortality in the sample plus actual drug use, treatment, and medical factors associated with drug dependence, focusing on possible gender differences.
Methods: Prospective follow-up study of 214 heroin-dependent patients consecutively admitted for MMT between 1980 and 1984 in the Asturias Public Health Service. The standardized mortality ratio (SMR) and 95% confidence interval (CI) were calculated. An ad-hoc protocol on drug misuse and treatment, drug-related morbidity and Clinical Global Impression (CGI) scores were assessed in the survivors' sample.
Results: Information was received on 159 subjects, 106 of whom were deceased. Men accounted for 76.2% of the study cohort. Over the 25-year follow-up period, the SMR was 22.51 (95% CI = 22.37-22.64). In the survivors sample, 39.6% were still enrolled in MMT; human immunodeficiency virus (HIV) was diagnosed in 47.2% and hepatitis B/C in 81.1%; current heroin use was reported by 22.6%. There were no gender differences in mortality or HIV and hepatitis B/C status. None of the female survivors were using heroin at the 25-year follow-up compared with 31.1% of males.
Conclusions: This study confirms the high mortality of heroin addicts even after enrollment in MMT. Severity of the addiction in terms of mortality was similar in both genders. Women who survived the 25-year follow-up were more likely to have stopped using heroin than men.
Affiliation : Department of Psychiatry, University of Oviedo, c/Julian Claveria 6, 33006 Oviedo, Spain Permalink : http://bdoc.ofdt.fr/index.php?lvl=notice_display&id=68015[article]Long term outcomes of pharmacological treatments for opioid dependence: does methadone still lead the pack? / M. P. GARCIA-PORTILLA ; M. T. BOBES-BASCARAN ; M. T. BASCARAN ; P. A. SAIZ ; J. BOBES in British Journal of Clinical Pharmacology, Vol.77, n°2 (February 2014)
in British Journal of Clinical Pharmacology > Vol.77, n°2 (February 2014) . - 272-284
Titre : Long term outcomes of pharmacological treatments for opioid dependence: does methadone still lead the pack? Type de document : Périodique Auteurs : M. P. GARCIA-PORTILLA ; M. T. BOBES-BASCARAN ; M. T. BASCARAN ; P. A. SAIZ ; J. BOBES Année de publication : 2014 Article en page(s) : 272-284 Langues : Anglais Mots-clés : Thésaurus TOXIBASE
OPIOIDES ; HEROINE ; TRAITEMENT DE MAINTENANCE ; PHARMACOTHERAPIE ; METHADONE ; BUPRENORPHINE ; NALOXONE ; PRODUIT DE SUBSTITUTION
Discipline : TRA Traitement et prise en charge / Treatment and care Domaine : Drogues illicites / Illicit drugs Résumé : The aim of this review was to update and summarize the scientific knowledge on the long term outcomes of the different pharmacological treatment options for opioid dependence currently available and to provide a critical discussion on the different treatment options based on these results. We performed a literature search using the PubMed databases and the reference lists of the identified articles. Data from research show that the three pharmacological options reviewed are effective treatments for opioid dependence with positive long term outcomes. However, each one has its specific target population and setting. While methadone and buprenorphine are first line options, heroin-assisted treatment is a second line option for those patients refractory to treatment with methadone with concomitant severe physical, mental, social and/or functional problems. Buprenorphine seems to be the best option for use in primary care offices. The field of opioid dependence treatment is poised to undergo a process of reinforcement and transformation. Further efforts from researchers, clinicians and authorities should be made to turn new pharmacological options into clinical reality and to overcome the structural and functional obstacles that maintenance programmes face in combatting opioid dependence. Sous-type de document : Revue de la littérature / Literature review Refs biblio. : 50 Affiliation : Department of Psychiatry and CIBERSAM, University of Oviedo, Oviedo, Spain Permalink : http://bdoc.ofdt.fr/index.php?lvl=notice_display&id=75203[article]